Endocrine Abstracts

Acromegaly secondary to ectopic growth hormone-releasing hormone (GHRH) is rare accounting for less than 1% of cases of acromegaly. Less than 100 cases have been reported in the literature mainly as case reports, except for a nationwide French series of 21 cases. Ectopic acromegaly occurs more frequently in women who represent 2/3 of cases. Median age at diagnosis is 41 years but ranges from adolescence to elderly. GHRH secreting neuroendocrine tumors are usually well differen...

Introduction: Dopamine agonists (DA), reference treatment for microprolactinomas, rarely allow long term remission. The performance of endoscopic pituitary surgery should be examined as first-line treatment.Objective: To evaluate the remission rate of microprolactinoma operated by endoscopic transphenoidal approachMethods: We retrospectively studied the surgical results of the 35 microprolactinomas operated between 2010 to 2017 in ...

Context: The immune checkpoint inhibitor (ICI) therapy is frequently used to treat advanced cancers. Autoimmune adverse events have been reported, such as endocrine side effects including frequent thyroid disorders and more rarely hypophysitis. The aim of this study was to describe retrospectively the association thyroiditis-hypophysitis.Patients and method: From 99 patients with endocrine side effects of the ImmuCare cohort, 18 patients with hypophysiti...

Introduction: Usually GHD women require higher GH doses than males, especially those with exogenous oestrogens (guidelines). This fact was assessed in real-life practice in France.Methods: Data were from a Registry in 84 sites treating AGHD (Norditropin®) up to 5 years. Naïve patients did not receive GH 6 months before inclusion. Statistics were descriptive.Results: 328 patients (129 naïve) were included; mean age 49...

TSH secreting pituitary adenomas are rare tumours for which the treatment of choice is neurosurgery but in some cases medical treatment with somatostatin analogs (SSA) can lead to a good control of symptoms and shrinkage of the tumour.The objective of this study was to review 30 patients diagnosed with TSH-omas between October 1981–July 2014, followed-up for a median of 43.93 months (1.12–192.11) in our University Hospital from Lyon, France.</p...

Objective: The management of pituitary apoplexy, a rare emergency neuroendocrine condition, is controversial. The aim of the present study was to compare the outcome of patients with pituitary apoplexy managed either by a conservative or surgical approach.Methods: A retrospective cohort study including patients diagnosed between 2007 and 2018 in a tertiary French university hospital. Pituitary apoplexy score was retrospectively applied in a perspective o...

Objective: Guidelines recommend using fine needle aspiration cytology (FNAC) to guide thyroid nodule surgical indication, however to what extent these guidelines are followed remains unclear. This study aimed to analyze the quality of the preoperative care pathway and the influence of the care pathway on surgical indications relevance.Design: Nationwide historical cohort study based on data from a sample (1/97th) of French health insurance beneficiaries....

Differentiated thyroid cancer is rare in children and adolescents. An aggressive clinical presentation, together with a high rate of recurrences contrasting with low mortality, has been reported, especially, before the age of 15 years. Data are mainly issued from historical series from hospital databases.The aim of the study was to analyze, from a population-based registry, the clinical presentation and outcome of differentiated thyroid cancer in young s...

Objective: Silent corticotroph adenomas (SCA) are rare pituitary tumours immunoreactive for ACTH but without clinical evidence of Cushing’s disease. They have been compared to non functioning pituitary adenomas or ACTH adenomas with Cushing’s disease, but no distinction has been made between micro and macro ACTH-adenomas. We characterize SCA on clinical, hormonal and molecular data and compared the characteristic of these tumours with those of macro (MCA) and micro A...

Objective: IGF1 is the most useful serum marker for GH dose titration in adults. The authors focused on the GH dose adjustment with extreme IGF1 values (<−2S.D.; >+2S.D.).Methods: French observational study of AGHD patients treated with Norditropin®.Prospective follow up until 5 years.Results (median [Q1; Q3]):: 328 AGHD, 39.2±14.3 years old wer...